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Acta Biomater
2015 May 8:1-6
respctively
CAS Number: 87679-37-6
L-penicillamine (SNAP) (30 and 100 nM)
CID755673 amine with linker Acta BiomaterCID 755673 is a selective protein kinase D (PKD) inhibitor. CID 755673 was identified from the National Institutes of Health small molecule repository library of 196,173 compounds. In cell based assays, CID755673 blocked phorbol ester induced endogenous PKD1 activation in LNCaP cells in a concentration dependent manner. CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. In summary, our findings indicate that